What is the length of the protein encoded by the human SREBF1 gene?
26 kb
In this paper we describe the cloning and characterization of the human SREBF1 gene. The gene is 26 kb in length and has 22 exons and 20 introns.
What hormone stimulates lipogenesis?
Insulin promotes lipogenesis, thereby resulting in the storage of triglycerides in adipocytes and of low-density lipoproteins (LDL) in hepatocytes. Insulin stimulates lipogenesis by activating glucose import, regulating the levels of glycerol-3-P and lipoprotein lipase (LPL).
How is Srebp regulated?
SREBP processing is mainly controlled by cellular sterol content. When sterol levels decrease, the precursor is cleaved to activate cholesterogenic genes and maintain cholesterol homeostasis.
How does Srebp regulate cholesterol synthesis?
Sterol regulatory element binding proteins (SREBPs) are membrane-bound transcription factors that activate genes involved in cholesterol synthesis. They provide the means by which cellular cholesterol exerts negative feedback on cholesterol synthesis.
What is the function of SREBP-1c?
SREBP-1c is a transcription factor which is synthetized as a precursor in the membranes of the endoplasmic reticulum and which requires post-translational modification to yield its transcriptionally active nuclear form. Insulin activates the transcription and the proteolytic maturation of SREBP-1c.
What does insulin do to SREBP1c?
Insulin activates the transcription and the proteolytic maturation of SREBP-1c. SREBP-1c induces the expression of a family of genes involved in glucose utilization and fatty acid synthesis and can be considered as a thrifty gene.
What causes SREBP-1c to be elevated?
Evidence indicates that the fatty liver of insulin resistance is caused by SREBP-1c, which is elevated in response to the high insulin levels. Thus, SREBP-1c levels are elevated in the fatty livers of obese (ob/ob) mice with insulin resistance and hyperinsulinemia caused by leptin deficiency (38, 39).
Is there a role for SREBP-1c in dyslipidaemia and Type 2 diabetes?
Since a high lipid availability is deleterious for insulin sensitivity and secretion, a role for SREBP-1c in dyslipidaemia and type 2 diabetes has been considered in genetic studies and some association demonstrated.
