What does the PRNP gene do?
The PRNP gene provides instructions for making a protein called prion protein (PrP), which is active in the brain and several other tissues. Although the precise function of this protein is unknown, researchers have proposed roles in several important processes.
What is human prion protein?
A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally. Prion diseases can affect both humans and animals and are sometimes spread to humans by infected meat products. The most common form of prion disease that affects humans is Creutzfeldt-Jakob disease (CJD).
Where is protein sequence in UniProt?
Retrieving sequences from the website
- Perform your favorite query and view the resulting list of entries (e.g. this query retrieves all UniProtKB entries that are part of the human proteome: proteome:UP000005640)
- Click the Download button in the query result page.
Is UniProt a protein database?
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature.
What does PrP protein do?
The PrP has been shown to participate in several biological processes, including neuritogenesis, neuronal homeostasis, cell signalling, cell adhesion, and a protective role against stress.
Can prion proteins be destroyed?
To destroy a prion it must be denatured to the point that it can no longer cause normal proteins to misfold. Sustained heat for several hours at extremely high temperatures (900°F and above) will reliably destroy a prion.
What kind of database is UniProt?
The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).
The PRNP gene provides instructions for making a protein called prion protein (PrP), which is active in the brain and several other tissues. Although the precise function of this protein is unknown, researchers have proposed roles in several important processes.
What is the functional relation between the alternative prion protein (altprp) and PRNP?
Cited for: BICISTRONIC GENE. The alternative prion protein/AltPrP (AC F7VJQ1) and PRNP have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon.Curated
Is there a human PRNP cDNA?
Kretzschmar et al. (1986) isolated a PRNP cDNA from a human retina cDNA library. The 253-amino acid protein shared 90% amino acid sequence identity with the hamster protein. Northern blot analysis detected a 2.5-kb mRNA in a variety of human neuroectodermal cell lines.
What is the structure of PrPC protein?
The nonpathogenic cellular human prion protein, PrPc, is a glycoprotein that contains a single disulfide bond, is N-glycosylated, and is attached to the plasma membrane by a C-terminally linked glycosyl phosphatidylinositol anchor.
