Is STAT3 anti inflammatory?
In this context, STAT3 has a key antiinflammatory role by maintaining the ability of Foxp3+ Tregs to inhibit inflammatory Th17 cells [214–216].
What activates STAT3?
STAT3 is activated by several pro-inflammatory cytokines, including interleukin-6 (IL-6)24,25,26, which is a prime target for therapeutic intervention in several inflammatory diseases including rheumatoid arthritis, Still’s disease and giant cell arthritis.
What is the function of STAT3?
Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis). The STAT3 protein is active in tissues throughout the body.
What happens when STAT3 is phosphorylated?
Function. STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator.
Where is STAT3 found in the cell?
cytoplasm
STAT3 is found in the cytoplasm and is activated in response to stimuli from the cytokines. Activated STAT3 regulates the transcription of genes controlling cell survival and proliferation and regulates the expression of antiapoptotic and immune response genes [128–130].
How does STAT3 promote resistance to therapy?
Persistent STAT3 activity can also enhance stem cell-like and mesenchymal properties, making obstruction of the pathway through which it signals a potentially attractive therapeutic strategy. In several studies, increasing in number through the last few years, STAT3 has also been implicated in resistance to radiation.
Is STAT3 an oncogene?
Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors first characterized for their role in cytokine signaling.
What does STAT3 regulate?
STAT3 is a key transcription factor and regulates a multitude of genes important for proliferation, differentiation, apoptosis, inflammation and tumorigenesis. STAT3 expression and activity are regulated through alternative splicing, post-translational modification and subcellular localization.
What type of protein is STAT3?
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family.
What happens to STAT3 after phosphorylation?
In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), form homo- or heterodimers, and translocate to the cell nucleus where they act as transcription activators.
