What is wet granulation method?
Wet Granulation: The process of adding a liquid solution to powders involves the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent that must be volatile, so that it can be removed by drying, and be non-toxic.
What is high-shear wet granulation?
A high-shear wet granulation process involves a granulation bowl equipped with an impeller blade that provides agitation and imparts high-shear to the powder during granulation. The bowl contains a chopper that helps to break-up large agglomerates formed during granulation.
What is spray granulation?
The spray granulation process converts a water-containing solution, paste or suspension or a melt into a granule. The granulation and the drying processes take place at the same time. Any kind of crystallization and mechanical dewatering equipment can be replaced by an SGS type fluid bed.
What is a wet granulator?
Wet granulation is a process that involves combining different particles of powder together using liquid solutions and adhesives. Binding of the particles often occur through a boost action from an impeller and leads to an enlargement of particles.
What is rapid mixer granulator?
Rapid mixer granulator is used for granulation in pharmaceutical manufacturing. It is used to mix the pharmaceutical ingredients and make the granules before compression and also called a high shear mixer. Impellers and chopper are mainly responsible for wet granulation in the rapid mixer granulator.
What is high shear mixer granulator?
A high-shear granulator consists of a cylindrical or conical mixing bowl, a three-bladed impeller, a chopper, an auxiliary chopper, a motor to drive the blades and a discharge pot. Binder addition or addition of granulating liquid. Wetting of powder and nucleation. Growth of granules and densification of the powder.
Is wet granulation better than dry granulation?
Advantages of wet granulation Granules formed are relatively more spherical than the powders and have better flow properties. 2. Improved compressibility of powders resulting from wet granulation process allows the use of low pressure during compression.
What is the advantage of wet granulation?
1 Introduction
| Wet granulation | |
|---|---|
| Advantages | • More uniform mixing than dry granulation • More binding in less quantity of binder • Better content uniformity • Suitable for very low to very high drug content • Reduces sticking of blend to compression tooling |
What are advantages of wet granulation method?
What is chopper in RMG?
Chopper is designed at the lower side of RMG, which helps break down a large mass of granules into tiny granules. A chopper is used whenever required and operated at a speed of 1440-2880 rpm. The chopper does not have any advantage on the size of granules when the impeller speed is high( about 200 rpm).
What is high shear granulation and how does it work?
High shear granulation is a shaping process for granulation that has been enhanced for application in the pharmaceutical industry. A binder liquid is fed to the powder particles in a closed container with blending tools and a chopper. Dense granules are formed through the liquid and solid bridges that result.
How to improve the granulation distribution of granules?
Today, an improved dosed distribution using a spray nozzle is preferred in order to obtain a more even granulate. The granules are distinguished by a compact structure and high bulk density. They have good flow characteristics and can be optimally pressed.
What is the purpose of agglomeration and granulation?
Our processes for agglomeration and granulation have the purpose of shaping powder solids. The goal of these technologies is to make product handling easier and to enhance the properties of the starting material for dosage or further processing.
