What is poloxamer used for?
What is it? Poloxamers are polymers used for drug delivery as formulation excipients. They are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. They are also used in topical dosage forms and rectal suppositories.
What is poloxamer made of?
Poloxamer is composed of triblock copolymers of polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO), shown in Fig. 9.13 [115]. As a nonionic surfactant, the synthetic polymer has been previously used in drug delivery and medical imaging applications.
Is poloxamer a detergent?
Poloxamer is a non-ionic detergent that protects cells from hydrodynamic damage. It can be also used for in vitro isolation of lymphocytes from diluted whole blood. Miscible with water.
What is a poloxamer gel?
Poloxamers are peculiar synthetic tri-block copolymers composed of two poly(ethylene oxide) units and a poly(propylene oxide) one with amphiphilic properties. The dual character, confers to the copolymers interesting properties that can be controlled and changed by different PPO/PEO ratios.
Is poloxamer 407 toxic?
Potential degradation by sonication. Wang et al. reported that aqueous solutions of poloxamer 188 and poloxamer 407 sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can become highly toxic to cultured cells. The toxicity correlated with the sonolytic degradation of the polymers.
Is poloxamer 188 a surfactant?
Poloxamer 188 is a synthetic surfactant that is a multiblock copolymer.
Is poloxamer a surfactant?
It is more commonly called Pluronic® (BASF). Since the middle block is hydrophobic and the two end blocks are hydrophilic, the poloxamer behaves as polymer surfactant. It is used as nonionic polymer surfactant. They can function as antifoaming agents, wetting agents, dispersants, thickeners, and emulsifiers.
Is poloxamer water-soluble?
Poloxamers, available also under the trademark Pluronics® (BASF), are a class of water-soluble nonionic A-B-A and B-A-B triblock copolymers, where A is poly(ethylene oxide) (PEO) and B is poly(propylene oxide) (PPO).
Is poloxamer a surfactant 407?
Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature.
How do you dissolve a poloxamer?
Poloxamer 407 aqueous solutions can be prepared by two methods; in both, the solubilization of the polymer in the aqueous phase is the starting point, but in the “cold” procedure, the dissolution is performed at 4 °C until a clear solution is formed, while in the “hot” method, the aqueous phase is heated to 70–90 °C.
What are the side effects of poloxamer 407?
They are costly, and are known to cause side effects including ectopic bone formation, formation of seroma,9) neuropathy by neuritis, osteolysis, and soft tissue swelling. Moreover, the risk of retrograde ejaculation,11) male infertility and malignancy were also recently reported.
What is poloxamer 407 used for in mouthwash?
Poloxamer 407 is used in mouthwash to allow the blending of unblendable liquids. While research into the effects of poloxamer 407 on humans is ongoing, it is thought to be highly toxic and linked to breast cancer. This begs the question; why is it included in mouthwash? Saccharin is an artificial sweetener.
