Is Zimeldine a styrenes?
Zimeldine is a member of styrenes. One of the SEROTONIN UPTAKE INHIBITORS formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of GUILLAIN-BARRE SYNDROME associated with its use. (From Martindale, The Extra Pharmacopoeia, 29th ed, p385)
What is the concentration of zimelidine in blood?
Blood concentrations of zimelidine and its metabolite norzimelidine were 0.71 and 2.2 mg/L respectively. Concentrations of the drug and metabolite are also given for the urine, liver, bile, and brain. Zimelidine was the first marketed selective serotonin reuptake inhibitor (SSRI) antidepressant.
Is Zimeldine a 5-HT reuptake blocker?
The pharmacokinetics of zimeldine, a 5-HT reuptake blocker with antidepressive effects, was studied after a single oral dose and after multiple oral administration in 19 alcoholic males, 10 with and 9 without chronic liver damage.
What are the side effects of Zimeldine and amitriptyline?
Whereas amitriptyline produced more autonomic, cardiovascular side effects, tremor, drowsiness and diarrhea, zimeldine produced inner tension, headaches, nausea, arthralgia, and decreased appetite and appeared to adversely affect sleep. There were 4 episodes of hypersensitivity reaction with zimeldine.
