How is iv imipenem administered?

Administer 500 mg by intravenous infusion over 20 to 30 minutes. Administer 1000 mg by intravenous infusion over 40 to 60 minutes. In patients who develop nausea during the infusion, the rate of infusion may be slowed.

Who should not take imipenem?

chronic kidney disease stage 3A (moderate) chronic kidney disease stage 3B (moderate) chronic kidney disease stage 4 (severe) chronic kidney disease stage 5 (failure)

Why imipenem is given with cilastatin?

The use of a fixed combination of imipenem and cilastatin is motivated by the increases in urinary recovery of imipenem with the combination and by the elimination of the nephrotoxic potential associated with the administration of imipenem alone.

What is IV imipenem used for?

Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections.

How do you administer Tienam?

Method of administration TIENAM is to be reconstituted and further diluted (see section 6.2, 6.3 and 6.6) prior to administration. Each dose of ≤500 mg/500 mg should be given by intravenous infusion over 20 to 30 minutes. Each dose >500 mg/500 mg should be infused over 40 to 60 minutes.

Does imipenem need renal adjustment?

Adult patients with a CrCl < 90 mL/minute and pediatric patients with a CrCl <= 50 mL/minute require adjustments of their imipenem dose. The FDA-approved labeling recommends that adult patients with renal failure (CrCl < 15 mL/minute) should not receive imipenem unless hemodialysis is instituted within 48 hours.

What is the difference between imipenem and meropenem?

Imipenem, the first carbapenem, was first marketed in 1987; meropenem was introduced to the market in 1996. In general, imipenem is more active against Gram-positive cocci while meropenem is more active against Gram-negative bacilli. The agents display similar pharmacokinetics.

Can imipenem be given orally?

Absorption and distribution. Imipenem is not absorbed by the oral route. No accumulation of imipenem is reported following multiple dosing with cilastatin. Imipenem and cilastatin are both widely distributed in multiple fluids and tissues.

What is cilastatin mechanism?

Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.

How do you dilute imipenem?

Each 500mg of dose should be diluted with 100ml of compatible IV fluid, whilst for a 1gm dose use a 250ml bag. Infuse doses of 500mg over 20 minutes. Infuse doses of 500mg to 1gm over 40 to 60 minutes.

What is another name for imipenem?

Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections.

What is the nickname for imipenem?

Imipenem/cilastatin