Can I take omeprazole and clopidogrel together?
Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.
What are risks of concurrent use of nsaids and antiplatelet therapy clopidogrel with Ppis?
CONCLUSION — Concurrent use of clopidogrel and a proton pump inhibitor (PPI) may result in decreased levels of the clopidogrel active metabolite, and possibly its antiplatelet activity, but whether it results in clinically significant adverse cardiovascular outcomes is not clear.
Which PPI is safe with clopidogrel?
However, based on data from in vitro pharmacokinetic studies, the FDA suggest that pantoprazole is the least likely to interact [54]. Stockley’s Drug interactions suggest that pantoprazole is the least likely to interact with clopidogrel and also suggest lansoprazole and rabeprazole as suitable alternatives [9].
Can you take atorvastatin with omeprazole?
omeprazole atorvastatin Combining these medications may increase the blood levels and effects of atorvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue.
Can you take clopidogrel and atorvastatin together?
Talk to your doctor before using atorvastatin and clopidogrel. This combination may reduce the effects of clopidogrel. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity.
Why omeprazole should be avoided in patient using clopidogrel?
Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopidogrel’s active metabolite by 50% and to sharply increase platelet reactivity, as a result of inhibition by omeprazole of CYP2C19, a cytochrome P450 (CYP) enzyme.
Does omeprazole inhibit CYP2C19?
Omeprazole inhibits CYP2C19 and therefore its own metabolism. This leads to non-linear pharmacokinetics. The AUC response to dose increases is greater than linear in normal metabolizer patients at doses exceeding 40 mg.
Can I take omeprazole with blood pressure medication?
Adding omeprazole to long-term amlodipine therapy in patients with hypertension and ARD may lead to a significantly more pronounced antihypertensive effect in patients genotyped CYP2C19 IMs.
Does clopidogrel cause acid reflux?
All drugs have side effects but most people will not experience them. Clopidogrel can cause stomach upset or heartburn. If this happens, always take your clopidogrel after food or with a glass of milk. If you develop heartburn, indigestion or your bowel motions become black, contact your doctor for further advice.
Can you take omeprazole with blood pressure medicine?
Does omeprazole interact with clopidogrel?
Nevertheless, pharmacodynamic studies suggest that omeprazole might attenuate the antiplatelet effect of clopidogrel. However, in observational studies, this interaction does not appear to translate into increased cardiovascular risk in patients treated with this combination.
Does clopidogrel interact with other medications or PPIs?
Currently Medsafe does not have sufficient information about interactions between clopidogrel and PPIs other than omeprazole and esomeprazole to be able to make specific recommendations.
Is omeprazole an inhibitor of CYP2C19?
Clopidogrel is a prodrug that is converted to its active form by drug metabolising enzymes CYP3A4 and 3A5, with contributions from CYP2C19, CYP2C9, and CYP1A2. Proton pump inhibitors are frequently co-prescribed with clopidogrel to reduce the gastrointestinal irritation associated with clopidogrel use. Omeprazole is an inhibitor of CYP2C19.
How many mg of clopidogrel should I take for ASA?
Clopidogrel added to ASA therapy at the first medical visit, Open label 75 mg once a day will be given to all individuals as part of the protocol (since main outcome of interest is clopidogrel effect. Actual comparison arms are double blind ranitidine and omeprazole. Other Names:
